Pediatric Endocrinology MCQ
Three years old boy presented with goiter, short stature, deafness and symptoms
suggestive of mild hypothyroidism. On examination, was having normal mentality,
diffuse goiter, deaf and mute with normal CNS examination apart from sluggish
reflexes. His bone age was retarded and has raised level of circulating TSH, fT4 and
Among which of the following is most likely diagnosis?
a) Generalized resistance to thyroid hormone (GRTH)
b) Pituitary resistance to thyroid hormone (PRTH)
c) Pendred's syndrome
d) TSH secreting Adenoma
e) Congenital thyroid hypoplasia
Generalized resistance to thyroid hormone
2. The following is not contraindication for growth hormone replacement
therapy in children?
a) Active malignancy
b) Proliferative retinopathy in a child with diabetes and growth hormone
c) Severe scoliosis
d) Within six months of post surgical removal of pituitary tumor
e) Presence of other pituitary hormone deficiencies.
Presence of other pituitary hormone deficiencies is not one of
3. The following is not proven adverse effect of growth hormone replacement?
a) Carpal tunnel syndrome
b) Arthralgia and myalgia
c) Benign intracranial hypertension
d) Insulin resistance and hyperglycemia
e) Increase incidence and recurrences of brain tumor
Increase incidence and recurrences of brain tumor is never documented
and is not proven adverse effect of growth hormone therapy
Ten year old girl presented with obesity, round plethoric face, hirsuitism and short
stature. On examination her blood pressure was high and her obesity was truncal.
the following laboratory finding is expected to find?
a) Metabolic acidosis
d) Hypokalemia and metabolic alkalosis
e) Suppressed cortisol level
Suppressed cortisol level
Six month old male infant presented with failure to thrive, constipation. His mother
was complaining of too many diaper change and urine was leaking out of diapers
most of the time. On examination he was having moderate to severe dehydration. His
initial sodium was high 175 mmol/l., very low urine osmolality.
Which of the
following is least common cause in the diffential diagnosis of this infant?
a) Langerhans cell histeocytosis
b) X-linked recessive form of nephrogenic diabetes insipidus
c) DIDMOAD syndrome
d) Pituitary germ cell tumor
e) Psychological polydepsia
because the age of this infant is six month, the least common cause will be
in this scenario is Psychological polydepsia
6. Which of the following is Not a cause of the acquired form of nephrogenic
a) Lithium toxicity
d) Post obstructive uropathy
e) Vasopressin receptor gene mutation
Vasopressin receptor gene mutation is the cause of primary nephrogenic DI
not the acquired form.
7. Which of the following is not in the differential diagnosis of primary
a) Conn's syndrome
b) Bilateral adrenal hyperplasia
c) Glucocorticoid suppressible hyperaldestronism
d) Aldestrone –producing adrenal carcinoma
e) Bilateral renal artery stenosis
Bilateral renal artery stenosis is cause of secondary not primary
8. When adenyl cyclase is activated, which of the following is true?
a) cAMP is formed
b) cAMP is broken
c) G-proteins bind to cAMP
d) G-proteins are important for all hormones to work
e) steroid hormones enter the cell
cAMP is formed
9. Somatostatin is secreted by?
a) Pancreatic F-cells
b) Pancreatic delta cells
c) zona fasciculata
d) parafollicular cells
e) posterior pituitary
pancreatic delta cells
Eleven year old young boy who had presented to the clinic because of short
stature. Height was much below 3
. percentile and weight was on 75
Which is the following is important in your initial evaluation?
a) Measure parents height and calculate mid-parental height
b) Assure him that his short stature is not pathological
c) Admit immediately to do growth hormone stimulation test
d) Start growth hormone treatment, if clinically suggestive of GH
e) Start short trial of growth hormone and see the response.
Measure parent's height and calculate mid-parental height (an important
initial evaluation measure in child with short stature)
Four year old girl, brought by her mother because of bilateral breast enlargement,
advancement of growth and spotty vaginal discharges.
Which is the most
important initial investigation you will order?
a) LH/FSH and estrogen
b) HCG (Human chorionic gonadotropin)
d) Thyroid function test
e) GnRH stimulation test to differentiate central from peripheral type
LH/FSH and estrogen (all investigations mentioned are needed,
most important initial investigation
is statement (a).
Which is the following statement is true regarding precocious puberty?
a) Usually defined as onset of puberty less than 6 years in girls and 7
years in boys
b) Idiopathic cause is the commonest cause in females with central
c) Hypothalamic hamartoma is the least common cause of central
d) Usually, not serious problem and doesn’t require investigation.
e) MRI brain is mandatory in all cases with precocious puberty
regardless of type.
Idiopathic cause is the commonest cause in females with central
13. Oxytocin is secreted by?
c) zona glomerulosa
d) pars intermedia
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